QUEM SOMOS?

Equipe multidisciplinar de pesquisadores da área de ciencias biológicas dedicados à investigação dos processos moleculares envolvidos no desenvolvimento do câncer e progressão para o câncer agressivo e metastático

FUZIWARA, C.S.

Cesar Seigi Fuziwara

Jovem Pesquisador da FAPESP, pós-doutor e ex-prof. Colaborador III (programa PART/USP).

Orientador do Programa de Pós-graduação em Biologia de Sistemas-ICB/USP

Formado em Ciências Biológicas pela Universidade de São Paulo, possui Mestrado e Doutorado em Ciências pelo ICB/USP,

Pós-doutorado na USP e na Universidade da Califórnia Berkeley.

Links: Curriculo Lattes e Biblioteca FAPESP

KIMURA, E.T.

Edna Teruko Kimura

Professora Titular do Instituto de Ciências Biomédicas da Universidade de São Paulo (ICB/USP)

Chefe do Laboratório de Biologia Molecular e Edição Gênica do Câncer

Coordenadora do Nucleo de Pesquisa em MicroRNAs (NApmiR/USP)

Links: Curriculo Lattes, Biblioteca FAPESP e site ICB.

DE MELLO, D.C.

Aluno de Doutorado no Programa de Pós-graduação em Biologia de Sistemas do Instituto de Ciências Biomédicas da Universidade de São Paulo (ICB/USP).

Formado em Biomedicina pela Universidade Paulista (UNIP).

Bolsista FAPESP.

Links: Curriculo Lattes e Biblioteca FAPESP

Diego Claro de Mello

MENEZES, J.M.

Joice Moraes Menezes

Mestre pelo Programa de Pós-graduação em Biologia de Sistemas do Instituto de Ciências Biomédicas da Universidade de São Paulo (ICB/USP).

Formada em Ciências Biológicas pela Universidade Estadual do Norte do Paraná.

Bolsista FAPESP.

Links: Curriculo Lattes e Biblioteca FAPESP

de OLIVEIRA, A.T.F.

Antônio Tarelo Freitas de Oliveira

Aluno de Mestrado no Programa de Pós-graduação em Biologia de Sistemas do Instituto de Ciências Biomédicas da Universidade de São Paulo (ICB/USP).

Formado em Ciências Biomédicas pela Universidade de São Paulo

Links: Curriculo Lattes e Biblioteca FAPESP

CRISTOVÃO, M.M.

Marcella Maringolo Cristovão

Aluna de Mestrado no Programa de Pós-graduação em Biologia de Sistemas do Instituto de Ciências Biomédicas da Universidade de São Paulo.

Formada em Ciências Biológicas pela Universidade de São Paulo

Links: Curriculo Lattes e Biblioteca FAPESP

de GÓIS, G.A.

Guilherme Alves de Góis

Aluna de Iniciação Científica do Instituto de Ciências Biomédicas da Universidade de São Paulo.

Graduando em Ciências Biológicas pela Universidade de São Paulo

Links: Curriculo Lattes e Biblioteca FAPESP

OLIVEIRA, P.L.S.

Pedro Lucas da Silva Oliveira

Aluna de Iniciação Científica do Instituto de Ciências Biomédicas da Universidade de São Paulo (ICB/USP). Bolsista PIBIC/CNPq.

Graduando em Ciências Biomédicas na Universidade de São Paulo

Links: Curriculo Lattes

SAITO, K.C

Kelly Cristina Saito

Especialista de Laboratório e responsável pelo Setor de Técnicas Avançadas em Biologia Molecular do Depto. de Biologia Celular e do Desenvolvimento

Formada em Ciências Biológicas pela UNESP

Possui Mestrado e Doutorado em Ciências pela Universidade de São Paulo.

Links: Curriculo Lattes

Ex-membros

Alunos egressos

SILVA, A.L.G.L.

Amanda Luvisotto Gomes Leite Silva

Aluna de Iniciação Científica do Instituto de Ciências Biomédicas da Universidade de São Paulo (ICB/USP). Bolsista FAPESP.

Graduanda em Ciências Biomédicas na Universidade de São Paulo

Links: Curriculo Lattes e Biblioteca FAPESP

ARTIGOS PUBLICADOS

Referências e links para artigos

Equipe e Publicações: Publicações

Conheça como contribuímos com a Ciência:

Junho de 2024

Epigenetic Regulation of DLK1-DIO3 Region in Thyroid Carcinoma
Alves LF, da Silva IN, de MELLO DC, FUZIWARA CS, Guil S, Esteller M, Geraldo MV.

Cells. 2024 Jun 8;13(12):1001. doi: 10.3390/cells13121001

https://pubmed.ncbi.nlm.nih.gov/38920632/

https://www.mdpi.com/2073-4409/13/12/1001

Abril de 2024

Editorial: New molecular pathways in thyroid cancer and pathophysiology: role of coding and noncoding genes
FUZIWARA CS, Nicola JP, Geraldo MV.

Front Endocrinol (Lausanne). 2024 Apr 5;15:1404305. doi: 10.3389/fendo.2024.1404305. eCollection 2024.

https://pubmed.ncbi.nlm.nih.gov/38645428/

https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1404305/full

Abril de 2023

Modulation of EZH2 Activity Induces an Antitumoral Effect and Cell Redifferentiation in Anaplastic Thyroid Cancer
de MELLO DC, SAITO KC, CRISTOVÃO MM, KIMURA ET, FUZIWARA CS.

Int J Mol Sci . 2023 Apr 26;24(9):7872. doi: 10.3390/ijms24097872.

https://pubmed.ncbi.nlm.nih.gov/37175580/

https://www.mdpi.com/1422-0067/24/9/7872

Abril de 2022

hnRNP A1 and hnRNP C associate with miR-17 and miR-18 in thyroid cancer cells
dos Santos MGP, Gatti da Silva GH, Nagasse HY, FUZIWARA CS, KIMURA ET, Coltri PP.

FEBS Open Bio. 2022 Jun;12(6):1253-1264. doi: 10.1002/2211-5463.13409.

https://febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.13409

Fevereiro de 2022

Muscle Stem Cell Function Is Impaired in β2-Adrenoceptor Knockout Mice
Koike TE, FUZIWARA CS, Brum PC, KIMURA ET, Rando TA, Miyabara EH.

Stem Cell Reviews and Reports. .

https://link.springer.com/article/10.1007/s12015-022-10334-y

Fevereiro de 2022

Gene Editing with CRISPR/Cas Methodology and Thyroid Cancer: Where Are We?
FUZIWARA CS, de MELLO DC, KIMURA ET.

Cancers 2022, 14(3), 844; https://doi.org/10.3390/cancers14030844

https://pubmed.ncbi.nlm.nih.gov/35159110/

https://www.mdpi.com/2072-6694/14/3/844

Julho de 2021

Targeting the highly expressed microRNA miR-146b with CRISPR/Cas9n gene editing system in thyroid cancer
SANTA-INEZ DC, FUZIWARA CS, SAITO KC, KIMURA ET.

Int. J. Mol. Sci. 2021, 22, 7992. https://doi.org/ 10.3390/ijms22157992

https://pubmed.ncbi.nlm.nih.gov/34360757/

https://www.mdpi.com/1422-0067/22/15/7992

Julho de 2021

miR-200 deficiency promotes lung cancer metastasis by activating cancer-associated fibroblasts
Xue B, Chuang CH, Prosser HM, FUZIWARA CS, Chan C, Sahasrabudhe N, Kühn M, Wu Y, Chen J, Biton A, Chen C, Wilkinson JE, McManus MT, Bradley A, Winslow MM, Su B, He L.

Genes Dev. 2021 Jul 22. doi: 10.1101/gad.347344.120.

https://pubmed.ncbi.nlm.nih.gov/34301766/

http://genesdev.cshlp.org/content/early/2021/07/22/gad.347344.120.full.pdf+html

Janeiro de 2021

Age-related increase of let-7 family microRNA in rat retina and vitreous.
Akamine PS, Lima CR, Lustoza Costa GJ, FUZIWARA CS, Del Debbio CB, KIMURA ET, Santos MF, Hamassaki DE.

Exp Eye Res. 2021 Jan 4:108434. doi: 10.1016/j.exer.2020.108434.

https://pubmed.ncbi.nlm.nih.gov/33412132/

Novembro de 2020

Genetic Mutations and Variants in the Susceptibility of Familial Non-Medullary Thyroid Cancer.
Miasaki FY, FUZIWARA CS, Carvalho GA, KIMURA ET.

Genes (Basel). 2020 Nov 18;11(11):1364. doi: 10.3390/genes11111364..

https://pubmed.ncbi.nlm.nih.gov/33218058/

Março de 2020

How does microRNA modulate Wnt/β-catenin signaling in thyroid oncogenesis?

FUZIWARA CS, KIMURA ET.

Ann Transl Med. 2020 Mar;8(6):266. doi: 10.21037/atm.2020.02.152.

https://pubmed.ncbi.nlm.nih.gov/32355710/

Janeiro de 2020

Thyroid follicular cell loss of differentiation induced by microRNA miR-17-92 cluster is attenuated by CRISPR/Cas9n gene silencing in anaplastic thyroid cancer.

FUZIWARA CS, SAITO KC, KIMURA ET.

Thyroid. 2020 Jan;30(1):81-94. doi: 10.1089/thy.2018.0601. Epub 2019 Oct 31.

https://pubmed.ncbi.nlm.nih.gov/31578932/

Setembro de 2019

Interplay of TGF β signaling and microRNA in thyroid cell loss of differentiation and cancer progression.

FUZIWARA CS, SAITO KC, KIMURA ET.

Arch Endocrinol Metab. 2019 Sep 2;63(5):536-544. doi: 10.20945/2359-3997000000172. eCollection 2019

https://pubmed.ncbi.nlm.nih.gov/31482959/

Março de 2019

The highly expressed FAM83F protein in papillary thyroid cancer exerts a pro-oncogenic role in thyroid follicular cells.
FUZIWARA CS, SAITO KC, Leoni SG, Waitzberg ÂFL, KIMURA ET.

Front Endocrinol (Lausanne). 2019 Mar 1;10:134. doi: 10.3389/fendo.2019.00134. eCollection 2019.

https://pubmed.ncbi.nlm.nih.gov/30881348/

Novembro de 2018

Osteoglycin post-transcriptional regulation by miR-155 induces cellular architecture changes in H9C2 cardiomyoblasts.
de Oliveira G, Freire PP, Omoto ACM, Cury SS, FUZIWARA CS, KIMURA ET, Dal-Pai-Silva M, Carvalho RF.

Gene. 2018 Nov 15;676:9-15. doi: 10.1016/j.gene.2018.07.020. Epub 2018 Jul 7.

https://pubmed.ncbi.nlm.nih.gov/29990505/

Julho de 2018

Functional toll-like receptor 4 overexpression in papillary thyroid cancer by MAPK/ERK-induced ETS1 transcriptional activity.
Peyret V, Nazar M, Martin M, Quintar AA, Fernandez EA, Geysels RC, FUZIWARA CS, Montesinos MM, Maldonado CA, Santisteban P, KIMURA ET, Pellizas CG, Nicola JP, Masini-Repiso AM.

Mol Cancer Res. 2018 May;16(5):833-845. doi: 10.1158/1541-7786.MCR-17-0433. Epub 2018 Mar 9.

https://pubmed.ncbi.nlm.nih.gov/29523762/

Novembro de 2017

Osteoglycin inhibition by microRNA miR-155 impairs myogenesis.
Freire PP, Cury SS, de Oliveira G, Fernandez GJ, Moraes LN, da Silva Duran BO, Ferreira JH, FUZIWARA CS, KIMURA ET, Dal-Pai-Silva M, Carvalho RF.

PLoS One. 2017 Nov 21;12(11):e0188464. doi: 10.1371/journal.pone.0188464. eCollection 2017https://pubmed.ncbi.nlm.nih.gov/29161332/

Maio de 2017

Identification of long noncodig RNAs deregulated in papillary thyroid cancer and correlated with BRAFV600E mutation by bioinformatics integrative analysis.
Goedert L, Plaça JR, FUZIWARA CS, Machado MCR, Plaça DR, Almeida PP, Sanches TP, Santos JFD, Corveloni AC, Pereira IEG, de Castro MM, KIMURA ET, Silva WA Jr, Espreafico EM.

Sci Rep. 2017 May 10;7(1):1662. doi: 10.1038/s41598-017-01957-0.

https://pubmed.ncbi.nlm.nih.gov/28490781/

Dezembro de 2016

MicroRNAs in Thyroid Development, Function and Tumorigenesis.

FUZIWARA CS, KIMURA ET.

Mol Cell Endocrinol. 2017 Nov 15;456:44-50. doi: 10.1016/j.mce.2016.12.017. Epub 2016 Dec 21.

https://pubmed.ncbi.nlm.nih.gov/28011236/

Dezembro de 2016

The effects of urban particulate matter on the nasal epithelium by gender: an experimental study in mice.
Yoshizaki K, FUZIWARA CS, Brito JM, Santos TMN, KIMURA ET, Correia AT, Amato-Lourenço LF, Vasconcellos P, Silva LF, Brentani MM, Mauad T, Saldiva PHN, Macchione M.

Environ Pollut. 2016 Jun;213:359-369. doi: 10.1016/j.envpol.2016.02.044. Epub 2016 Mar 1.

https://pubmed.ncbi.nlm.nih.gov/26942683/

Fevereiro de 2016

microRNA-146b-5p upregulates migration and invasion of different papillary thyroid carcinoma cells..

Lima CR, GERALDO MV, FUZIWARA CS, KIMURA ET, Santos MF.

BMC Cancer. 2016 Feb 16;16:108. doi: 10.1186/s12885

https://pubmed.ncbi.nlm.nih.gov/26883911/

Março de 2016

MAPK and SHH pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma..

Rommiti M, Wajner SM, Ceolin L, Ferreira CV, Ribeiro RV, Rohenkohl HC, Weber S de S, Lopez PL, FUZIWARA CS, KIMURA ET, Maia AL.

Endocr Relat Cancer. 2016 Mar;23(3):135-46. doi: 10.1530/ERC-15-0162

https://pubmed.ncbi.nlm.nih.gov/26825960/

Setembro de 2015

Insights into regulation of the miR-17-92 cluster of microRNAs in cancer..

FUZIWARA CS & KIMURA ET.

Front Med (Lausanne). 2015 Sep 8;2:64. doi: 10.3389/fmed.2015.00064. eCollection 2015.

https://pubmed.ncbi.nlm.nih.gov/26442266/

Agosto de 2015

The impact of a non-functional thyroid receptor beta upon triiodotironine-induced cardiac hypertrophy in mice.

do IMPÉRIO GE, RAMOS IP, SANTIAGO LA, PEREIRA GF, DOS SANTOS ALMEIDA NA, FUZIWARA CS, PAZOS-MOURA CC, KIMURA ET, OLIVARES EL, ORTIGA-CARVALHO TM.

Cell Physiol Biochem. 2015;37(2):477-90. doi: 10.1159/000430370. Epub 2015 Aug 28.

https://pubmed.ncbi.nlm.nih.gov/26315584/

EM CONSTRUÇÃO ....

QUEM SOMOS?

FUZIWARA, C.S.

KIMURA, E.T.

DE MELLO, D.C.

MENEZES, J.M.

de OLIVEIRA, A.T.F.

CRISTOVÃO, M.M.

de GÓIS, G.A.

OLIVEIRA, P.L.S.

SAITO, K.C

Ex-membros

SILVA, A.L.G.L.

ARTIGOS PUBLICADOS

Epigenetic Regulation of DLK1-DIO3 Region in Thyroid Carcinoma Alves LF, da Silva IN, de MELLO DC, FUZIWARA CS, Guil S, Esteller M, Geraldo MV.

Editorial: New molecular pathways in thyroid cancer and pathophysiology: role of coding and noncoding genes FUZIWARA CS, Nicola JP, Geraldo MV.

Modulation of EZH2 Activity Induces an Antitumoral Effect and Cell Redifferentiation in Anaplastic Thyroid Cancer de MELLO DC, SAITO KC, CRISTOVÃO MM, KIMURA ET, FUZIWARA CS.

hnRNP A1 and hnRNP C associate with miR-17 and miR-18 in thyroid cancer cells dos Santos MGP, Gatti da Silva GH, Nagasse HY, FUZIWARA CS, KIMURA ET, Coltri PP.

Muscle Stem Cell Function Is Impaired in β2-Adrenoceptor Knockout Mice Koike TE, FUZIWARA CS, Brum PC, KIMURA ET, Rando TA, Miyabara EH.

Gene Editing with CRISPR/Cas Methodology and Thyroid Cancer: Where Are We? FUZIWARA CS, de MELLO DC, KIMURA ET.

Targeting the highly expressed microRNA miR-146b with CRISPR/Cas9n gene editing system in thyroid cancer SANTA-INEZ DC*, FUZIWARA CS*, SAITO KC, KIMURA ET.

miR-200 deficiency promotes lung cancer metastasis by activating cancer-associated fibroblasts Xue B, Chuang CH, Prosser HM, FUZIWARA CS, Chan C, Sahasrabudhe N, Kühn M, Wu Y, Chen J, Biton A, Chen C, Wilkinson JE, McManus MT, Bradley A, Winslow MM, Su B, He L.

Age-related increase of let-7 family microRNA in rat retina and vitreous. Akamine PS, Lima CR, Lustoza Costa GJ, FUZIWARA CS, Del Debbio CB, KIMURA ET, Santos MF, Hamassaki DE.

Genetic Mutations and Variants in the Susceptibility of Familial Non-Medullary Thyroid Cancer. Miasaki FY, FUZIWARA CS, Carvalho GA, KIMURA ET.

How does microRNA modulate Wnt/β-catenin signaling in thyroid oncogenesis?

FUZIWARA CS, KIMURA ET.

Thyroid follicular cell loss of differentiation induced by microRNA miR-17-92 cluster is attenuated by CRISPR/Cas9n gene silencing in anaplastic thyroid cancer.

FUZIWARA CS, SAITO KC, KIMURA ET.

Interplay of TGFβ signaling and microRNA in thyroid cell loss of differentiation and cancer progression.

FUZIWARA CS, SAITO KC, KIMURA ET.

The highly expressed FAM83F protein in papillary thyroid cancer exerts a pro-oncogenic role in thyroid follicular cells. FUZIWARA CS, SAITO KC, Leoni SG, Waitzberg ÂFL, KIMURA ET.

Osteoglycin post-transcriptional regulation by miR-155 induces cellular architecture changes in H9C2 cardiomyoblasts. de Oliveira G, Freire PP, Omoto ACM, Cury SS, FUZIWARA CS, KIMURA ET, Dal-Pai-Silva M, Carvalho RF.

Osteoglycin inhibition by microRNA miR-155 impairs myogenesis. Freire PP, Cury SS, de Oliveira G, Fernandez GJ, Moraes LN, da Silva Duran BO, Ferreira JH, FUZIWARA CS, KIMURA ET, Dal-Pai-Silva M, Carvalho RF.

MicroRNAs in Thyroid Development, Function and Tumorigenesis.

FUZIWARA CS, KIMURA ET.

The effects of urban particulate matter on the nasal epithelium by gender: an experimental study in mice. Yoshizaki K, FUZIWARA CS, Brito JM, Santos TMN, KIMURA ET, Correia AT, Amato-Lourenço LF, Vasconcellos P, Silva LF, Brentani MM, Mauad T, Saldiva PHN, Macchione M.

Lima CR, GERALDO MV, FUZIWARA CS, KIMURA ET, Santos MF.

Rommiti M, Wajner SM, Ceolin L, Ferreira CV, Ribeiro RV, Rohenkohl HC, Weber S de S, Lopez PL, FUZIWARA CS, KIMURA ET, Maia AL.

FUZIWARA CS & KIMURA ET.

do IMPÉRIO GE, RAMOS IP, SANTIAGO LA, PEREIRA GF, DOS SANTOS ALMEIDA NA, FUZIWARA CS, PAZOS-MOURA CC, KIMURA ET, OLIVARES EL, ORTIGA-CARVALHO TM.

.

Epigenetic Regulation of DLK1-DIO3 Region in Thyroid Carcinoma
Alves LF, da Silva IN, de MELLO DC, FUZIWARA CS, Guil S, Esteller M, Geraldo MV.

Editorial: New molecular pathways in thyroid cancer and pathophysiology: role of coding and noncoding genes
FUZIWARA CS, Nicola JP, Geraldo MV.

Modulation of EZH2 Activity Induces an Antitumoral Effect and Cell Redifferentiation in Anaplastic Thyroid Cancer
de MELLO DC, SAITO KC, CRISTOVÃO MM, KIMURA ET, FUZIWARA CS.

hnRNP A1 and hnRNP C associate with miR-17 and miR-18 in thyroid cancer cells
dos Santos MGP, Gatti da Silva GH, Nagasse HY, FUZIWARA CS, KIMURA ET, Coltri PP.

Muscle Stem Cell Function Is Impaired in β2-Adrenoceptor Knockout Mice
Koike TE, FUZIWARA CS, Brum PC, KIMURA ET, Rando TA, Miyabara EH.

Gene Editing with CRISPR/Cas Methodology and Thyroid Cancer: Where Are We?
FUZIWARA CS, de MELLO DC, KIMURA ET.

Targeting the highly expressed microRNA miR-146b with CRISPR/Cas9n gene editing system in thyroid cancer
SANTA-INEZ DC, FUZIWARA CS, SAITO KC, KIMURA ET.

miR-200 deficiency promotes lung cancer metastasis by activating cancer-associated fibroblasts
Xue B, Chuang CH, Prosser HM, FUZIWARA CS, Chan C, Sahasrabudhe N, Kühn M, Wu Y, Chen J, Biton A, Chen C, Wilkinson JE, McManus MT, Bradley A, Winslow MM, Su B, He L.

Age-related increase of let-7 family microRNA in rat retina and vitreous.
Akamine PS, Lima CR, Lustoza Costa GJ, FUZIWARA CS, Del Debbio CB, KIMURA ET, Santos MF, Hamassaki DE.

Genetic Mutations and Variants in the Susceptibility of Familial Non-Medullary Thyroid Cancer.
Miasaki FY, FUZIWARA CS, Carvalho GA, KIMURA ET.

Interplay of TGF β signaling and microRNA in thyroid cell loss of differentiation and cancer progression.

The highly expressed FAM83F protein in papillary thyroid cancer exerts a pro-oncogenic role in thyroid follicular cells.
FUZIWARA CS, SAITO KC, Leoni SG, Waitzberg ÂFL, KIMURA ET.

Osteoglycin post-transcriptional regulation by miR-155 induces cellular architecture changes in H9C2 cardiomyoblasts.
de Oliveira G, Freire PP, Omoto ACM, Cury SS, FUZIWARA CS, KIMURA ET, Dal-Pai-Silva M, Carvalho RF.

Osteoglycin inhibition by microRNA miR-155 impairs myogenesis.
Freire PP, Cury SS, de Oliveira G, Fernandez GJ, Moraes LN, da Silva Duran BO, Ferreira JH, FUZIWARA CS, KIMURA ET, Dal-Pai-Silva M, Carvalho RF.

The effects of urban particulate matter on the nasal epithelium by gender: an experimental study in mice.
Yoshizaki K, FUZIWARA CS, Brito JM, Santos TMN, KIMURA ET, Correia AT, Amato-Lourenço LF, Vasconcellos P, Silva LF, Brentani MM, Mauad T, Saldiva PHN, Macchione M.